是的，despite、although和though存在明显的区别。区别解释。词性和用法。1.despite：是一个介词，其后通常接名词、短语或者从句，表示&ldquo；尽管、不管&rdquo。如：*Despite the heavy rain.they continued their journey.*。2.although：是一个连词，用于引导让步状语从句，表示&ldquo；虽然、尽管&rdquo。如：*Although he was tired.he kept working.*。