1、含义不同：How many times：多少次，几次，提问次数，Howoften：多长时间一次。2、询问对象不同：How many times：询问次数，How many times has your mother told you never to talk to strangers？你母亲告诉你多少次了，绝不能和陌生人谈话？Howoften：询问频率How often do you brush your teeth？你多久刷一次牙。