法国赛比克-微胶囊包裹技术

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Delivery systems A new activity at SEPPIC

January2010

Membranes Matrices Inclusions or sponges Active ingredient

Membrane

Active ingredient

Matrix

Active ingredient

Solid porous

support●Solid

-FilmThere is no universal technology

The best choice depends on:

releasedProperties

Emulsions - Liquid membranes\n\nExternal Medium (biological acquaeous medium)\n\nSurfactant\n\nGel in oil emulsion\nVolume (%) 10 100 90 80 70 60 50 40 30 20\n\nW/O emulsion\n\n50 µm Internal Water Internal Gel\n\n10 0 0.01 0 0.1 1.0 10.0 100.0 1000.0 Particle Diameter (µm.)\n\nSize distribution of a gel in oil emulsion\n\n4470/GB/January2010\n7\n\n\r\n

Emulsions - liquid membranes\n\nExperimental device\n\nRelease profiles can be monitored and predicted by mathematical models\n\nMontanide DDS 51 F: mineral oil Montanide DDS 763A: ester Montanide DDS 720: squalene\n\nRelease of encapsulated caffeine\n\n4470/GB/January2010\n8\n\n\r\n

Coatings\nMechanism of film formation\nSpraying Wetting Drying Film formation\n\nParticule Droplet of coating solution\n\nLaboratory and pilot equipment in SEPPIC’s labs\n\nVentilated pan coater\n\nFluidized bed\n4470/GB/January2010\n9\n\n\r\n

Granulation\nAtomisation Wet granulation\n\n4470/GB/January2010\n10\n\n\r\n

Hydrophilic matrices (compression)\nHydrophilic matrices made of hypromellose\n\n-- Predicted kinetics of dissolution\n\nDesired kinetics of dissolution\n\n6 punch rotative tabletting machine in SEPPIC’s lab\n\nHYMAT® model is able to calculate the suitable tablet composition to achieve a predefined release profile of an active ingredient.\n\nDissolution device\n4470/GB/January2010\n11\n\n\r\n

Hydrophilic pearls (dripping)\nAlginate and PVA pearls\nSolution of sodium Alginate and active ingredient\nMicrobeads Alginate /Volatile biocide 50/50\n100 90 80 70\n% biocide weight loss\n\nNon encapsulated biocide\n\n60 50 40 30 20 10 0 0 1 2 3 4\nTime ( hours )\n\nEncapsulated biocide in alginate capsules: Not crosslinked Crosslinked with 2% of Glutaraldehyde Crosslinked with 5% of Glutaraldehyde\n\n5\n\n6\n\n7\n\n8\n\nGelation bath (CaCl2 solution)\n\nEx: Release of kinetics of a volatile biocide encapsulated in alginate microcapsules\n4470/GB/January2010\n12\n\n\r\n

This technologyMicrobeads200–1000µm

01234567

time(hours)

Release of an API from an micropearl containing50%of pharmaceutical surfactants and50%of APITo encapsulate

Main uses Sustained release

Taste masking Stabilisation of drugs051015202530354045

Perfume on coated solid support

Perfume on solid support

Perfume alone

A3step process

Our strengths and specificities